Updating evidence role corticosteroids severe sepsis septic shock
The bolus group was defined as those receiving treatment regimens with planned temporal interruptions to corticosteroid drug delivery.
Outcomes were grouped as follows: Hyperglycaemia was a commonly reported negative outcome of the use of glucocorticoids.
All analyses were conducted using a frequentist approach assuming a random-effects model, with an equal heterogeneity variance assumed for all comparisons, using the network suite of Stata commands, programmed by Ian White .
We intended to rank the interventions according to their probability to be best, second best, third best and so forth for the different outcomes.
An NMA was undertaken to combine results of all comparisons among interventions in a single analysis.
This approach makes use of both the direct comparisons available within trials and the indirect comparisons of interventions that can be made across trials when they use a common comparator intervention .
We performed a network meta-analysis (NMA) on the data used for the Cochrane review to establish the likely effectiveness of each drug and therapeutic regimen in adults with septic shock.
Data from trials of acute respiratory distress syndrome (ARDS) were included when separate data were available for participants with sepsis or when contact with study authors resulted in provision of the data.