Non sedating ssris
Sexual dysfunction The SSRIs as a class produce a variety of sexual side effects, including anorgasmia, decreased libido, impotence, and delayed ejaculation.
Analysis of the clinical trials suggests that fluvoxamine and fluoxetine are less likely to produce sexual side effects than paroxetine and sertraline.
Certain differences between SSRIs are clinically significant.Also, SSRIs have very different molecular structures. Zoloft (Sertraline hydrochloride) was the second SSRI to come to market in the United States, and it was approved by the FDA in December 30, 1991. Paxil (Paroxetine hydrochloride) was the third SSRI to come to market in the United States and was approved by the FDA in December 29, 1992. Chemical structure of Paroxetine differs from other SSRIs by having a piperidine ring.The first drug in the SSRI class was Prozac (Fluoxetine), which hit the United States market in 1987. Luvox (Fluvoxamine maleate) was the next SSRI FDA approved in December 05, 1994.SSRIs are called selective because they seem to affect serotonin significantly more than other neurotransmitters.Thus, the medications work by allowing the body to make the best use of the reduced amounts of serotonin that it has at the time.