Mitochondrial dna dating

Mitochondrial DNA is especially vulnerable because it has a limited ability to repair itself.As a result, reactive oxygen species easily damage mitochondrial DNA, causing cells to malfunction and ultimately to die.As people age, mitochondrial DNA accumulates damaging mutations, including deletions and other changes.

Somatic mutations occur in the DNA of certain cells during a person's lifetime and typically are not passed to future generations.It typically affects both ears and worsens gradually over time, making it difficult to understand speech and hear other sounds.This condition results from a combination of genetic, environmental, and lifestyle factors, many of which have not been identified.Cells that have high energy demands, such as those in the inner ear that are critical for hearing, are particularly sensitive to the effects of mitochondrial DNA damage.This damage can irreversibly alter the function of the inner ear, leading to hearing loss.

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