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There is some limited evidence that suggests that tolerance to nonbenzodiazepines is slower to develop than with benzodiazepines.
However, data is limited so no conclusions can be drawn.
For example, long-acting benzodiazepines have problems of drug accumulation especially in the elderly or those with liver disease, and shorter-acting benzodiazepines have a higher risk of more severe withdrawal symptoms.
In the case of the nonbenzodiazepines, zaleplon may be the safest in terms of next-day sedation, and − unlike zolpidem and zopiclone − zaleplon has been found to have no association with increased motor vehicle accidents even when taken for middle-of-the-night insomnia due to its ultrashort elimination half-life.
The nonbenzodiazepines are positive allosteric modulators of the GABA-A receptor.
sometimes referred to colloquially as "Z-drugs") are a class of psychoactive drugs that are very benzodiazepine-like in nature.
Abuse may lead to limited physical dependence or psychological dependence relative to those in schedule 3.
Has a low potential for abuse relative to those in schedule 4.
They are safer than the older barbiturates especially in overdosage and they may, when compared to the benzodiazepines, have less of a tendency to induce physical dependence and addiction, although these issues can still become a problem.
This has led to the Z-drugs becoming widely prescribed for the treatment of insomnia particularly in elderly patients.