Dating the brain injury article

, are based on analysis of human brains from teenagers with recent head injury and mouse models that recreate sports-related head impact and military-related blast exposure.The investigators also performed laboratory experiments and computer modeling.In many cases, they have lost the life they once led and the person they once were.Even if they can't verbalize this realization, they are aware that something is very different.However, the mechanisms that cause CTE and relationship to concussion, subconcussive injury and TBI remain poorly understood.

Early indicators of CTE pathology not only persisted long after injury but also spread through the brain, providing the best evidence to date that head impact, not concussion, causes CTE. The relationship is no longer equal - you are no longer partners in the same sense you were before the injury.Initially it becomes almost like a parent-child relationship where the survivor becomes dependent upon their healthy partner.Based on pathological findings in human cases, the researchers hypothesized that early CTE may result from damaged blood vessels in the brain that become leaky, resulting in blood proteins spilling into brain tissue and triggering brain inflammation.The researchers utilized a brain scan called dynamic contrast-enhanced magnetic resonance imaging (DCE-MRI) to detect leaky blood vessels in the brains of mice subjected to head impact.

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